SECTION II: BUILDING MANY WORLDS
Chapter 5 - Information Overload: Database Aesthetics
5.11 The Human Genome Project
5.11.1 At around the same time that the male and female bodies were being digitised and made available over the Internet, major advances were being made in the field of molecular biology as well, and scholars were being mobilised to map the entire human genome. The prospect of digitally mastering human genome has serious potential for making it possible to identify the sources of disease and in turn develop new medicines and methods of treatment. Thus, the genome project was almost immediately a focus of interest for the private sector, who saw a great possibility for profit in gene identification, which subsequently caused them to launched their own, parallel, research efforts.
5.11.2 Begun in 1990, the US Human Genome Project is a fifteen-year effort co-ordinated by the U.S. Department of Energy and the National Institutes of Health to identify all the estimated eight thousand genes in human DNA, determine the sequences of the three billion chemical bases that make up human DNA, store this information in databases, and develop tools for data analysis. To help achieve these goals, researchers also are studying the genetic makeup of several non-human organisms. These include the common human gut bacterium Escherichia coli, the fruit fly, and the laboratory mouse. A unique aspect of the U.S. Human Genome Project is that it is the first large scientific undertaking to address the ethical, legal, and social issues (ELSI) that may arise from the project.
5.11.3 One of the results of the Human Genome project is cloning DNA, cells, and animals. Human cloning was raised as a possibility when Scottish scientists at the Roslin Institute created the much-celebrated sheep "Dolly" This case aroused world-wide interest and concern because of its scientific and ethical implications. The feat, cited by Science magazine as the breakthrough of 1997, has also generated uncertainty over the meaning of "cloning," an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. To Human Genome Project researchers, cloning refers to copying genes and other pieces of chromosomes to generate enough identical material for further study. Cloned collections of DNA molecules (called clone libraries) enable scientists to produce increasingly detailed descriptions of all human DNA, which is the aim of the Human Genome Project. In January 1998, nineteen European countries signed a ban on human cloning. The United States supports areas of cloning research that could lead to significant medical benefits, and the Congress is yet to pass a bill to ban human cloning.
5.11.4 Much of this ambition for digitised genomes is driven by excitement for a new way of thinking and working and by a utopian vision of all information being accessible to all-the vision of a collective consciousness. But this ambition is equally fuelled by the potentially huge monetary returns it could generate. The most disturbing example is research in the field of genetics led by Carl Venter, also called the Bill Gates of genetic engineering. His claim to be able to beat the governmentıs plan to map the entire genome by four years has even James D. Watson, the discoverer of DNA, up in arms. The rush to patent genes as they are discovered has many speculating if our bodies will truly be owned by corporate interests.
5.11.5 It is more than a decade since the US genetic engineering company Genentech made both medical and legal history, first with the discovery of the gene that produces insulin and then by persuading a series of US courts that it had earned the right to patent its discovery. Just as digital libraries funded by governments and developed by university consortiums have their counterparts in the corporate sector, so too in the sphere of biotechnology. The Human Genome Project is funding thousands of scientists working at universities and research labs with a generous budget of three billion dollars and climbing. But the biotech world has become a type of a battlefield, with certain private companies refusing to share the genetic codes they identified and therefore claim. The case of the Staphylococus aurues, a deadly bacteria that resists the strongest antibiotics, is an example of this conflict. Biotechnology and drug companies have spent huge amounts of money on decoding the genome of the Staph, hoping to design new drugs to combat it. But they refuse to share their discoveries or to collaborate with federal health officials, forcing them to duplicate the work at a cost of millions of dollars to taxpayers. The question is still open and mirrors the one that is always looming over the Internet: Will information be available and free in the public domain, or will it be patented and owned by the large corporate sector? (Cimons, 1999, pg. A16) [top]